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Pyrimidine nucleoside analogues, for instance BVDU and BVaraU, may be degraded by pyrimidine catabolic enzymes (for instance uridine phosphorylase or thymidine phosphorylase (TPase) leading to their free of charge foundation metabolites with out antiviral action. BVDU cannot be administered together with 5-flurouracil or its prodrug capecitabine be